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Science, Patents & Purity

6 Patents Awarded

Helpful Tip: Approved Claims Are At The Very End Of Each Patent 

Patented To Increase AMPK Activation (US #11,690,851 B2)

Resolitrol Synergistically Increases AMPK Activation

  • Promotes Healthy Blood Sugar
  • Promotes Fat Burning
  • Decreases Fat And Cholesterol Synthesis
  • Promotes Mitophagy: Programmed Death And Replacement Of Poorly Functioning Mitochondria
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Patented To Increase Cellular Glucose Uptake (US #11,166,962 B2)

Resolitrol® Synergistically Increases Cellular Glucose Uptake

  • Promotes The Uptake Of Blood Sugar Into Muscle Tissue
  • Lowers Blood Sugar
View Patent
Patented To Decrease Obesity (US #11,642,354 B2)
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Patented To Treat Obesity (US #10,155,003 B2)
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Patented Composition Comprising Resveratrol And Ursolic Acid (US #10,583,145 B2)
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Patented Nutritional Supplement Comprising Resveratrol And Ursolic Acid (US #11,090,311 B2)
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Resolitrol® Synergistically Key Lowers Inflammatory Targets
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Purity

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References

  1. Junco JJ, Mancha A, Malik G, et al. Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. Mol Cancer Res. 2013;11(12):1521-1529. doi:10.1158/1541-7786.MCR-13-0237
  2. Cho J, Rho O, Junco J, et al. Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. Cancer Prev Res (Phila). 2015;8(9):817-825. doi:10.1158/1940-6207.CAPR-15-0098
  3. Lodi A, Saha A, Lu X, et al. Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism [published correction appears in NPJ Precis Oncol. 2017 Sep 4;1(1):30]. NPJ Precis Oncol. 2017;1:18. doi:10.1038/s41698-017-0024-z
  4. Brasnyó P, Molnár GA, Mohás M, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106(3):383-389. doi:10.1017/S0007114511000316
  5. Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-622. doi:10.1016/j.cmet.2011.10.002
  6. Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res (Phila). 2011;4(9):1419-1425. doi:10.1158/1940-6207.CAPR-11-0148
  7. Patel KR, Brown VA, Jones DJ, et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010;70(19):7392-7399. doi:10.1158/0008-5472.CAN-10-2027
  8. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-342. doi:10.1038/nature05354
  9. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127(6):1109-1122. doi:10.1016/j.cell.2006.11.013
  10. Park SJ, Ahmad F, Philp A, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012;148(3):421-433. doi:10.1016/j.cell.2012.01.017
  11. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997;275(5297):218-220. doi:10.1126/science.275.5297.218
  12. Tang X, Shi L, Xie N, et al. SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. Nat Commun. 2017;8(1):318. Published 2017 Aug 22. doi:10.1038/s41467-017-00396-9
  13. Peng L, Jiang D. Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition. PLoS One. 2018;13(10):e0205918. Published 2018 Oct 24. doi:10.1371/journal.pone.0205918
  14. Lee H, Zhang P, Herrmann A, et al. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci U S A. 2012;109(20):7765-7769. doi:10.1073/pnas.1205132109
  15. Lissa D, Senovilla L, Rello-Varona S, et al. Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci U S A. 2014;111(8):3020-3025. doi:10.1073/pnas.1318440111
  16. Ramírez-Rodríguez AM, González-Ortiz M, Martínez-Abundis E, Acuña Ortega N. Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation. J Med Food. 2017;20(9):882-886. doi:10.1089/jmf.2017.0003
  17. Qian Z, Wang X, Song Z, et al. A phase I trial to evaluate the multiple-dose safety and antitumor activity of ursolic acid liposomes in subjects with advanced solid tumors. Biomed Res Int. 2015;2015:809714. doi:10.1155/2015/809714
  18. Kunkel SD, Elmore CJ, Bongers KS, et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One. 2012;7(6):e39332. doi:10.1371/journal.pone.0039332
  19. Ullevig SL, Zhao Q, Zamora D, Asmis R. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis. 2011;219(2):409-416. doi:10.1016/j.atherosclerosis.2011.06.013
  20. Jang SM, Yee ST, Choi J, et al. Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. Int Immunopharmacol. 2009;9(1):113-119. doi:10.1016/j.intimp.2008.10.013
  21. Rao VS, de Melo CL, Queiroz MG, et al. Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. J Med Food. 2011;14(11):1375-1382. doi:10.1089/jmf.2010.0267
  22. Shanmugam MK, Ong TH, Kumar AP, et al. Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. PLoS One. 2012;7(3):e32476. doi:10.1371/journal.pone.0032476
  23. Gao N, Cheng S, Budhraja A, et al. Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. Br J Pharmacol. 2012;165(6):1813-1826. doi:10.1111/j.1476-5381.2011.01684.x
  24. Junco JJ, Cho J, Mancha A, et al. Role of AMPK and PPARα in the anti-skin cancer effects of ursolic acid. Mol Carcinog. 2018;57(12):1698-1706. doi:10.1002/mc.22890
  25. Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70(22):9003-9011. doi:10.1158/0008-5472.CAN-10-2364
  26. Zhu Z, Qian Z, Yan Z, Zhao C, Wang H, Ying G. A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. Int J Nanomedicine. 2013;8:129-136. doi:10.2147/IJN.S38271


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